1982 M.D., 1985 M.S., 1992 Ph.D. Seoul National University College of Medicine
Experience
1982-1983 Rotating internship, Seoul National University Hospital
1983-1986 Department of Pediatrics, Seoul National University Hospital
1989-1990 Clinical Fellow, Department of Pediatrics (Neonatology), Seoul National University, Children’s Hospital
1990-1992 Director of Nursery and NICU, Cha Women’s Hospital, Seoul, Korea
1992-1994 Visiting Research Fellow, University of Southern University, USA(Division of Neonatology, LAC-USC Medical Center, Women’s Hospital / Division of Infectious Disease, Children’s Hospital of Los Angeles)
1994-present Staff Pediatrician, Department of Pediatrics, Samsung Medical Center, Seoul, Korea
1997-2002 Associate Professor, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
2002-present Professor, Sungkyunkwan University School of Medicine, Korea
2007-2009 Chair, Department of Pediatrics, Samsung Medical Center, Seoul, Korea
2012-present Professor, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea
2012-2016 Vice president, Korean Society of Perinatology, Korea
2013-2019 Principal Investigator,Korean Neonatal Network(KNN), Korea
2017-2018 President, Korean Society of Perinatology, Korea
Journal Articles
(2022)
Intratracheal Transplantation of Mesenchymal Stem Cells Attenuates Hyperoxia-Induced Microbial Dysbiosis in the Lungs, Brain, and Gut in Newborn Rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
23,
12
(2022)
Efect of levothyroxine supplementation in extremely low birth weight infants with transient hypothyroxinemia of prematurity.
SCIENTIFIC REPORTS.
12,
1
(2022)
Thrombin Preconditioning Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in Severe Intraventricular Hemorrhage Induced Neonatal Rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
23,
8
(2022)
Increased Risk of Meconium-Related Ileus in Extremely Premature Infants Exposed to Antenatal Magnesium Sulfate.
NEONATOLOGY.
119,
1
(2021)
Bdnf-overexpressing engineered mesenchymal stem cells enhances their therapeutic efficacy against severe neonatal hypoxic ischemic brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
22,
21
(2021)
Cesarean section was not associated with mortality or morbidities advantage in very low birth weight infants: a nationwide cohort study.
SCIENTIFIC REPORTS.
11,
1
(2021)
Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage.
EXPERIMENTAL NEUROLOGY.
342,
(2021)
Stem cells for bronchopulmonary dysplasia in preterm infants: A randomized controlled phase II trial.
STEM CELLS TRANSLATIONAL MEDICINE.
10,
8
(2021)
Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia-associated late pulmonary hypertension in extremely preterm infants.
SCIENTIFIC REPORTS.
11,
1
(2021)
Mortality and Morbidities according to Time of Birth in Extremely Low Birth Weight Infants.
JOURNAL OF KOREAN MEDICAL SCIENCE.
36,
13
(2021)
Brain-derived neurotropic factor mediates neuroprotection of mesenchymal stem cell-derived extracellular vesicles against severe intraventricular hemorrhage in newborn rats.
STEM CELLS TRANSLATIONAL MEDICINE.
10,
3
(2021)
Mesenchymal stem cell therapy for intractable neonatal disorders.
PEDIATRICS AND NEONATOLOGY.
62,
(2020)
Conservative Non-intervention Approach for Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants.
FRONTIERS IN PEDIATRICS.
8,
(2020)
Antenatal magnesium sulfate treatment and risk of necrotizing enterocolitis in preterm infants born at less than 32 weeks of gestation (vol 10, 12826, 2020).
SCIENTIFIC REPORTS.
10,
1
(2020)
Survival rate dependent variations in retinopathy of prematurity treatment rates in very low birth weight infants.
SCIENTIFIC REPORTS.
10,
1
(2020)
Fish Oil Monotherapy for Intestinal Failure-Associated Liver Disease on SMOFlipid in the Neonatal Intensive Care Unit.
JOURNAL OF CLINICAL MEDICINE.
9,
11
(2020)
Mortality rate-dependent variations in antenatal corticosteroid-associated outcomes in very low birth weight infants with 23-34 weeks of gestation: A nationwide cohort study.
PLOS ONE.
15,
10
(2020)
Comparison of Respiratory Outcomes between Less Invasive Surfactant Administration and the Intubation- Surfactant-Extubation Technique in Premature Infants with Respiratory Distress Syndrome.
Neonatal medicine.
27,
3
(2020)
Effect of Nonintervention vs Oral Ibuprofen in Patent Ductus Arteriosus in Preterm Infants A Randomized Clinical Trial.
JAMA PEDIATRICS.
174,
8
(2020)
Sedation for Brain Magnetic Resonance Imaging in Preterm Infants: Using Propofol under Anesthesiologist Supervision.
Neonatal medicine.
27,
3
트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물(Compositions for Treating Chronic Lung Diseases Comprising Exosome Derived from Stem Cell Treated with Thrombin).
2018-551233.
20201117.
JAPAN
기관지 폐 이형성증 (BPD) 예방 또는 치료용 물질 스크리닝 방법(Method for screening substances for the prevention or treatment of bronchopulmonary dysplasia (BPD)).
10-2173-6730000.
20201028.
KOREA, REPUBLIC OF
WKYMVm 펩타이드를 유효성분으로 포함하는 과산소성 폐질환의 예방 또는 치료용 조성물
(composition for preventing or treating hyperoxia-induced lung injury comprising WKYMVm peptide as an active ingredient).
16/207,441__-____-_______.
20200908.
UNITED STATES
트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물(Compositions for Treating Chronic Lung Diseases Comprising Exosome Derived from Stem Cell Treated with Thrombin).
16/091,656.
20200728.
UNITED STATES
줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물.
14868825.2.
20200415.
EU
트롬빈을 이용한 줄기세포 유래 엑소좀의 생성 촉진 방법.
14869537.2.
20200219.
EU
신생아 ＨＩＥ 치료용 조성물.
10-2017-0142236.
20190422.
KOREA, REPUBLIC OF
줄기세포 유래 엑소좀을 포함하는 뇌혈관 질환 치료용도.
15/103663.
20190101.
UNITED STATES
Method for promoting generation of stem cell-derived exosome by using thrombin
(트롬빈을 이용한 줄기세포 유래 엑소좀의 생성 촉진 방법).
15/103,726.
20180529.
UNITED STATES
트롬빈을 이용한 줄기세포 유래 엑소좀의 생성 촉진 방법.
2016-539061.
20180525.
JAPAN
트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 피부상처 치료용 조성물(Compositions for Treating Skin Wound Comprising Exosome Derived from Stem Cell Treated with Thrombin).
10-2017-0080366.
20180515.
KOREA, REPUBLIC OF
Thrombin 처리 줄기세포에서 유래된 exosome을 포함하는 만성폐질환 치료용 조성물.
10-2016-0046197.
20180323.
KOREA, REPUBLIC OF
Method for treating an inflammatory brain disease comprising administering a stem dell-derived exosome
(줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌염증성 질환의 치료용 조성물).
15/126,053.
20180320.
UNITED STATES
줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌염증성 질환의 치료용 조성물.
2016-557971.
20180223.
JAPAN
줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물.
2016-539062.
20170810.
JAPAN
Composition for treating intraventricular hemorrhage in preterm infants comprising mesenchymal stem cells.
13/655,356.
20170110.
UNITED STATES
Meothod of treating lung diseases using cells separated or proliferated from umbilical cord blood.
12/184,695.
20161122.
UNITED STATES
Composition for treating developmental and/or chronic lung diseases comprising cells separated or proliferated from umbilical cord blood.
제 2,640,728 호.
20161018.
CANADA
줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물(Pharmaceutical composition for treating cerebrovascular disease comprising stem cell-derived exosome).
10-2014-0179541.
20160927.
KOREA, REPUBLIC OF
Honors / Awards
2014.12 Commendation of Minister of Health and Welfare from Commendation for the Promotion Healthcare Technology
2014.03 The 10th Bayer Clinical Medicine Award from Korean Academy of Medical Sciences
2010.11 Namyang Award from Korean Society of Perinatology
2009.10 Jinam Academic Award from Korean Society of Neonatology
2002.10 The second Jinam Academic Award from Korean Society of Neonatology
2001.10 The first Jinam Academic Award from Korean Society of Neonatology
2001.06 The thirty-fourth Yuhan Medical Award from Seoul Medical Association
1999.04 The fourth Sokchon Academic Award from Korean Pediatric Association
Conference Paper
(2021)
Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia‑associated late pulmonary hypertension in extremely preterm infants.
제71차 대한소아청소년과학회 추계학술대회.
KOREA, REPUBLIC OF
(2021)
Prevalence of hyperthyrotropinemia in the newborns admitted to the neonatal intensive care unit.
제71차 대한소아청소년과학회 추계학술대회.
KOREA, REPUBLIC OF
(2021)
초미숙아 생존율에 따른 출생 체중 500g 이하 아기의 예후 비교.
제71차 대한소아청소년과학회 추계학술대회.
KOREA, REPUBLIC OF
(2021)
출생체중 1,000-1,499 g 신생아에게 조기장관영양 프로토콜 적용 후 나타난 성장의 변화.
제71차 대한소아청소년과학회 추계학술대회.
KOREA, REPUBLIC OF
(2021)
Stem cell therapy for neonatal intraventricular hemorrhage.
대한신생아학회 제12차 교육세미나.
KOREA, REPUBLIC OF
(2021)
Umbilical cord blood-derived Mesenchymal Stromal Cell for intraventricular hemorrhage(IVH).
PAS 2021 VIRTUAL.
UNITED STATES
(2021)
Clinical trial results of stem cells therapy for bronchopulmonary dysplasia and intraventricular hemorrhage.
The 65th Annual Meeting of Japan Society for Neonatal Health and Development.
JAPAN
(2021)
Road to the Clinic of Stem Cell Therapy for Neonatal Intractable Disorders.
The 65th Annual Meeting of Japan Society for Neonatal Health and Development.
JAPAN
(2020)
출생체중 1,000-1,500 g 신생아에서 완전장관영양에 도달하는 시기와 신생아 괴사장염의 발생 (Time to reach full enteral feeding and necrotizing enterocolitis among infants 1,000-1,500 g weight at birth).
제70차 대한소아청소년과 추계학술대회.
KOREA, REPUBLIC OF
(2019)
신생아중환자실에서 주요 선천성 기형 신생아의 조기 진단을 위한 전장 염기서열 분석 적용.
제 69차 대한소아청소년과학회 추계학술대회.
KOREA, REPUBLIC OF
(2019)
신생아중환자실에서의 소아진정관리.
제 69차 대한소아청소년과학회 추계학술대회.
KOREA, REPUBLIC OF
(2019)
극소저체중출생아의 출생시간에 따른 사망률 및 예후.
제 69차 대한소아청소년과학회 추계학술대회.
KOREA, REPUBLIC OF
(2019)
재태연령 25주 미만에 발생한 조기 양막 파수 산모에게서 출생한 극소 저출생 체중아의 단기 결과; 한국 신생아 네트워크.
제 69차 대한소아청소년과학회 추계학술대회.
KOREA, REPUBLIC OF
(2019)
초미숙아에서 동맥관 개존의 치료 방침에 따른 급성 신손상의 발생률 및 예후 비교.
제 69차 대한소아청소년과학회 추계학술대회.
KOREA, REPUBLIC OF
(2019)
Conservative management of PDA in extremely preterm infants.
8th Annual Blue Mountains TINY TOTS Neonatal Conference.
AUSTRALIA
(2019)
Stem cell therapy for neonatal intractable disorders-a new hope for cure.
8th Annual Blue Mountains TINY TOTS Neonatal Conference.
AUSTRALIA
(2019)
Human umbilical cord blood derived mesenchymal stem cells: Magic cure for neonatal brain injuries?.
ISCT-CBA Cord Blood Series-pre conference workshop.
AUSTRALIA
(2019)
Thrombin preconditioning enhances therapeutic efficacy of human Wharton's jelly derived mesenchymal stem cells in severe neonatal hypoxic ischemic encephalopathy.
Pediatric Aademic Societies(PAS) 2019 Meeting.
UNITED STATES
(2019)
Mesenchymal stem cells: Magic cure for crerbral injury of preterm infants?.
2nd World Congress on Maternal Fetal Neonatal Medicine.
UNITED KINGDOM
(2019)
초미숙아 생존율 향상을 위한 실제적 방안.
삼성 신생아 심포지엄 2019.
KOREA, REPUBLIC OF
